Multiomics Analysis of Intestinal Injury in Hu Sheep Under Cadmium Exposure

Cadmium Accumulation and Its Impact on Agriculture and Animal Husbandry

Cadmium (Cd) is a toxic heavy metal widely present in soil, air, and water, with its levels increasing due to industrial development. This leads to cadmium accumulation in the food chain, affecting domestic animals. It enters the body through food, water, inhalation, and skin absorption, and its long half-life of 10-50 years can result in chronic health issues in humans. In agriculture and animal husbandry, cadmium accumulation in plants impacts crops and livestock, and as it enters the digestive system, it can cause gastrointestinal diseases. These diseases are difficult to prevent and treat, posing challenges to the industry.

Sheep Gut Microbiota and Disease Resistance

Research indicates that intestinal diseases in sheep are largely caused by microbial imbalances, which affect interactions between microbes and the host. Disease susceptibility varies among sheep breeds, and further study is needed to understand the mechanisms behind disease resistance and prevention. Hu sheep, a breed known for high fertility and growth, demonstrates variability in disease resistance, partly influenced by gut microbiome-host interactions. The intestinal tract plays a key role in animal growth, and while the causes of intestinal diseases like colitis are complex, cadmium exposure is a significant factor. The gut microbiota, functioning as a "second genome," is vital for nutrient metabolism, immune response, and overall health, highlighting the need for deeper exploration of its role in disease resistance.

Unlocking the Link: How TRF Influences Gut Microbiota and NAFLD

A recent study published in the journal Ecotoxicology and Environmental Safety, titled "Cadmium exposure promotes inflammation through the PPAR signaling pathway in the small intestine and colon of Hu sheep" (article resource) stressed Hu sheep exposed to cadmium in the environment were selected to investigate the underlying mechanism of inflammatory bowel disease development. Researchers employed 16S sequencing, untargeted metabolomics, and transcriptomic multiomics to examine alterations in the intestinal tract and its contents. The findings revealed a significant reduction in beneficial microorganisms (Ruminococcus sp.) in the cadmium group, alongside a marked increase in potentially harmful microbes. These microbial shifts impacted metabolites, particularly caprylic acid, leading to a decline in fatty acids within the intestine. The combined effects of cadmium ions and fatty acid reduction inhibited the PPAR signaling pathway, further impairing fatty acid transport and binding, ultimately resulting in severe intestinal damage. This research uncovered, for the first time, the mechanism of cadmium-induced intestinal injury in Hu sheep and proposed novel strategies for preventing and treating intestinal diseases associated with trace metal exposure in the environment.

MetwareBio: Your Trusted Partner in Multi-Omics Solutions

MetwareBio had offered the 16S sequencing, untargeted metabolomics and  transcriptomic services for this research. MetwareBio is a leading CRO specializing in cutting-edge multiomics technologies, advancing life sciences and health research. We are dedicated to providing high-quality data while tailoring our services to the unique needs of each project. MetwareBio offers comprehensive metabolomics, proteomics, and multi-omics analysis solutions, catering to a variety of research demands. Our workflows are flexible and can accommodate projects ranging from small-scale studies to large population-based research. Having successfully completed over 4,000 projects, we are known for delivering reliable results. At MetwareBio, we collaborate closely with researchers, offering full support from sample extraction to data analysis, ensuring accurate and efficient fulfillment of research goals. For any inquiries or specific requirements, don’t hesitate to reach out!