Serum/Plasma Quantitative Proteomics
Serum/Plasma Quantitative Proteomics
Efficient low-abundance proteins enrichment using magnetic beads
Profound detection depth with more low-abundance proteins detected
High sensitivity and resolution mass spectrometry platform
High-throughput 4D protein profiling detection technology
Technology Introduction
Blood Quantitative Proteomics is a specialized method developed specifically for blood samples. Blood contains a diverse range of proteins with significant differences in abundance, with high-abundance proteins dominating. In conventional proteomics, signals from low-abundance proteins relevant to many disease indicators in the blood are often overshadowed by signals from high-abundance proteins, resulting in fewer detected proteins. Our quantitative blood proteomics approach first enriches the middle-to-low abundance proteins in the blood using nanomagnetic beads. Subsequently, the samples are analyzed using the diaPASEF scanning mode, which offers high throughput, increased protein detection, and improved depth of analysis.
Applications of Blood Proteomics
Biomarker Discovery for Disease Diagnosis
Serum and plasma proteomics enables high-throughput identification of protein biomarkers associated with various diseases, including cancer, cardiovascular conditions, and metabolic disorders. This approach supports early detection and improves diagnostic accuracy through quantitative protein profiling.
Drug Target Identification and Validation
Quantitative proteomics helps uncover differentially expressed proteins in response to therapeutic interventions, aiding in the identification and validation of potential drug targets. Serum/plasma samples are especially valuable in preclinical and clinical drug development.
Mechanistic Insights into Disease Pathogenesis
By profiling protein expression patterns in serum or plasma, researchers can gain deeper understanding of the molecular mechanisms underlying disease onset and progression. This data supports the development of targeted treatment strategies and personalized medicine approaches.
Monitoring Treatment Response and Disease Progression
Serum/plasma proteomic analysis provides dynamic insights into treatment efficacy and disease progression. Quantitative changes in specific proteins can serve as non-invasive biomarkers for therapeutic monitoring in clinical settings.
Project Experience
Efficient enrichment of low-abundance proteins in blood samples, with an average detection of over 3,000 proteins, offering detailed insights for accurate proteomic analysis.
Average number of proteins identified
SERVICES
Bile Acid
Oxylipin Targeted Metabolomics
Neurotransmitter Targeted Metabolomics
Steroid Hormone Targeted Metabolomics
Energy Metabolism
Tryptophan Targeted Metabolomics
Amino Acid Targeted Metabolomics
Short-Chain Fatty Acids
Plant Hormone Assay
Carotenoid Targeted Metabolomics
Anthocyanin Assay
Gibberellin Assay
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Project Workflow of Serum/Plasma Quantitative Proteomics
1
Sample Shipment
2
Protein Extraction
3
Low-Abundant Proteins Enrichment
4
Trypsin Digestion
5
Data Acquisition
6
Database Search
7
Data Analysis
Sample Requirements of Blood Quantitative Proteomics
|
Samples |
Recommended Sample |
Size Minimum Sample Size |
|
Serum/Plasma |
100μL |
50μL |
WHAT'S NEXT IN OMICS: THE METABOLOME
Please submit a detailed description of your project. We will provide you with a customized project plan metabolomics services to meet your research requests. You can also send emails directly to support-global@metwarebio.com for inquiries.
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