TM Widely-Targeted Metabolomics
MetwareBio's TM widely-targeted metabolomics service delivers broad metabolite coverage and accurate relative quantification through an integrated untargeted and targeted LC-MS/MS strategy, enabling biomarker discovery, disease mechanism studies, drug response research, microbiome–host interaction analysis, and multi-omics studies.
TM Widely-targeted metabolomics is the 'Untargeted metabolomics + Targeted Metabolomics' process that achieves the perfect combination of high resolution, wide-coverage, high sensitivity, and precise quantification. It is a great starting point to examine the global metabolite profile. Metware's curated database of 280,000 metabolites, which includes 3000 metabolites not found in public databases, allows more annotations from high-resolution mass spec data.
Technology Introduction
"TM" Widely-Targeted Metabolomics combines Untargeted metabolomics and Targeted metabolomics to achieve the perfect combination of high-resolution, wide-coverage, high-sensitivity, and precise quantification. Metware's patented Widely-Targeted Metabolomics technology stands out from many others with features such as:
- Using high-resolution mass spectrometers to allow the unbiased collection of MS/MS spectrum data;
- Highly curated metabolomics database with over 3000+ in-house metabolite database providing more metabolite annotation;
- Using MRM analysis from QQQ to accurately quantify metabolites in each sample.
TM Widely-Targeted Matabolomics Service Technical Features
Large Curated Database
Collected ultra-high resolution data of over 280,000 metabolites. Each sample can typically identify over 1400 metabolites.
Rigorous Quality Control
A mature quality control system monitoring all aspects of experimentation from sample preparetion to data analysis.
Experienced
Stable and tested sample preparation protocol stemming from processing over a million samples a year.
Accurate Identification
Combining AB SCIEX QTOF 6600+ ultra-high resolution mass spectrum with our large curated database to achieve accurate metabolite identification.
Accurate Quantification
Using MRM mode from AB SCIEX Triple Quad 6500+ to achieve accurate relative quantification of metabolites.
Applications of TM Widely-Targeted Matabolomics Service
- Clinical marker discovery and development
- Understanding mechanisms behind disease progression
- Studying drug efficacy and toxicity
- Environmental toxicology research
TM widely-tagregetd Metabolomics Service Case Study
SERVICES
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List of Metabolites
The in-house standard database contains 3000 metabolites as shown below:
| Category | Quantity | Representative substance |
|---|---|---|
| Amino acids and their metabolites | 600+ | Glycine, L-threonine, L-arginine, N-acetyl-L-alanine |
| Organic acids and their derivatives | 400+ | 3-hydroxybutyric acid, adipic acid, hippuric acid, kynurenine |
| Nucleotides and their metabolites | 200+ | Adenine, 5'-Adenine Nucleotide, Guanine, 2'-Deoxycytidine |
| Carbohydrates and their metabolites | 100+ | D-glucose, glucosamine, D-fructose 6-phosphate |
| Lipid | 500+ | O-acetylcarnitine, γ-linolenic acid, lysophosphatidylcholine 22:4 |
| Benzene and its derivatives | 500+ | Benzoic acid, 3,4-dimethoxyphenylacetic acid, 4-hydroxybenzoic acid |
| Coenzymes and vitamins | 60+ | Folic acid, pantothenic acid, vitamin D3 |
| Alcohols, amines | 150+ | Dopamine, histamine, DL-1-amino-2-propanol |
| Aldehydes, ketones, esters | 120+ | Furfural, ethyl butyrate, α-pentyl cinnamaldehyde |
| Heterocyclic compound | 200+ | Pyridoxal, biopterin, indole-3-acetic acid |
| bile acid | 40+ | Glycocholic acid, deoxycholic acid, taurolithocholic acid |
| Hormones and hormone-related substances | 100+ | Juvenile hormone 3, epinephrine, 3,3'-diiodo-L-thyroxine |
| Tryptamine, choline, pigment | 15+ | Serotonin, bilirubin (E-E), urobilin |
| other | 50+ | Astaxanthin |
| total | 3000+ | |
Analysis Content Display of TM Widely-Targeted Metabolomics Service
Our complete service includes various data analyses to jump start your research. Below are a few components that you may find in our data analysis report.
SERVICES
Next-Generation Omics Solutions:
Proteomics & Metabolomics
Submit your inquiry to explore customized proteomics and metabolomics services for your research, or contact us at support-global@metwarebio.com..
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